Source: http://www.thehollywoodgossip.com/2013/02/national-margarita-day-drink-up/
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সোমবার, ২৫ ফেব্রুয়ারি, ২০১৩
Virtual GameBoy v3.7.5 for Android
| VGB emulates GameBoy handheld game consoles and their accessories. It will run GameBoy, GameBoy Pocket, GameBoy Color, and Super GameBoy games on your Android phone or tablet. VGB also supports the Pocket Printer, GameGenie cheat codes, and more. Please notice that VGB will not play GameBoy Advance games: you will need VGBA for that. VGB package itself does not contain any games. You should place your own game files onto the SD card before running VGB. Please, do not run any software you do not own with VGB. The author cannot and will not tell you where to find free GameBoy games. |
Virtual GameBoy v3.7.5 for Android Changelog:
* Optimized File Selector to show large directories faster and without crashing.
* Now showing more file information when there is no screenshot.
* Fixed alphabetical index in the File Selector.
* Added Legend of Zelda: Link's Awakening to the Cheatopedia.
* Added Legend of Zelda: Link's Awakening DX to the Cheatopedia.
Download: Virtual GameBoy v3.7.5 for Android
Source: Here
Source: http://www.emucr.com/2013/02/virtual-gameboy-v375-for-android.html
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French actor Depardieu gets Russian home address
MOSCOW (AP) ? French actor Gerard Depardieu has a new permanent address in Russia.
Depardieu had sought Russian citizenship as part of his battle against a proposed super tax on millionaires in France. President Vladimir Putin granted him a Russian passport last month, and on Saturday he got it stamped with his address in the provincial city of Saransk.
Saransk is a city of 300,000 about 640 kilometers (400 miles) east of Moscow, known for its 18th-century churches. Depardieu was registered in an apartment belonging to his friend's relatives.
Showing his knowledge of Russian history, Depardieu likened himself to Yemelyan Pugachev, the chief of a peasant rebellion of the 18th century, saying: "I am like Pugachev: I am a peasant, and I want to be tsar of Saransk," according to Russia Today television.
Source: http://news.yahoo.com/french-actor-depardieu-gets-russian-home-address-161033705.html
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LG Shows Off Wireless 4K Streaming, From Phone to TV
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রবিবার, ২৪ ফেব্রুয়ারি, ২০১৩
China acknowledges pollution-linked ?cancer villages?
China acknowledges pollution-linked ?cancer villages?
By Jenny Johnson
The environment ministry in China has accepted the existence of ?cancer villages?, after years of assertions by academics and domestic media that polluted areas experience higher rates of the disease.
The use of the term in an official report, thought to be unprecedented, comes as authorities face growing discontent over industrial waste, hazardous smog, and other environmental and health consequences of years of rapid growth.?Poisonous and harmful chemical materials have brought about many water and atmosphere emergencies... certain places are even seeing ?cancer villages?,? said a five-year plan that was highlighted this week.
The report did not elaborate on the phenomenon, which has no technical definition but gained prominence in domestic and foreign media after a Chinese journalist posted a map in 2009 pinpointing dozens of such ?cancer villages?.
The environment ministry acknowledged that in general, China uses ?poisonous and harmful chemical products? that are banned in developed countries and ?pose long-term or potential harm to human health and the ecology?.
Environmental lawyer Wang Canfa, who runs an aid centre in Beijing for victims of pollution, said it was the first time the ?cancer village? phrase had appeared in a ministry document.
?It shows that the environment ministry has acknowledged that pollution has led to people getting cancer,? he said. ?It shows that this issue, of environmental pollution leading to health damages, has drawn attention.?
A ministry official, who declined to be named, could not confirm whether it was the first time it had used the phrase, but said it had previously acknowledged the connection between the environment and human health.
Media reports about ?cancer villages? emerged as early as 1998.
Official sources such as government websites have altogether reported 241 such locations, a US-based geography professor said in a 2010 study.
The total reached 459 if accounts from ?unofficial? sites such as online portals were included, University of Central Missouri academic Lee Liu said in the US-based journal Environment.
The villages tended to be near major rivers, where people have congregated for generations but which also tended to attract industrial parks seeking easy access to water.
?Water contamination from industrial pollution is believed to be the main cause of cancer villages,? Liu wrote.
Cancer incidence has shot up 80% over the past three decades ? a period of breakneck economic growth ? to become the country?s most common cause of death, the China Daily cited the health minister as saying in 2010.
Today, 2.7m Chinese people die from cancer a year, the paper reported last month, citing the 2012 annual report from the Cancer Registry.
Frustration over industrial pollution has sparked several huge protests over the past year and forced officials to promise to shut plants.
Several days of thick smog that covered swathes of the country last month prompted a public outcry as well as rare criticism from state-run media and top government officials.
The pollution prompted a rise in hospital visits and forced flights to be cancelled as visibility dropped to as low as 100 metres.
HomeSource: http://feeds.irishexaminer.com/~r/ieworld/~3/kksIFP4UWiU/
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All personal, all business in fierce GOP opposition to Obama's pick of Hagel for Pentagon job
WASHINGTON - The fierce Republican opposition to President Barack Obama's nomination of Chuck Hagel to be defense secretary is personal and business.
The nasty fight long has been seen as a proxy for the never-ending scuffles between the Democratic president and congressional Republicans, with barely any reservoir of good will between the White House and lawmakers, and the GOP still smarting over the November election results.
Barring any surprises, the drawn-out battle over Hagel's nomination probably will end this coming week with his Senate confirmation. But his fellow Republicans have roughed him up.
A vote is expected on Tuesday.
In the weeks after Obama secured a second term, Republicans knocked out a presidential favorite, U.N. Ambassador Susan Rice, and dashed her secretary of state hopes over her widely debunked remarks about protests precipitating the assault on the U.S. diplomatic mission in Libya on Sept. 11.
Emboldened Republicans then set their sights on Hagel, whose GOP classification won him no points with the party.
The former two-term Nebraska senator was widely viewed as a political heretic. He disagreed with President George W. Bush over the Iraq war, stayed on the sidelines in the 2008 president race between Obama and the Republican nominee, Arizona Sen. John McCain, and endorsed fellow Vietnam veteran and former Democratic Sen. Bob Kerrey in last year's Nebraska Senate race.
Republicans remember it well.
"There's a lot of ill will toward Sen. Hagel because when he was a Republican, he attacked President Bush mercilessly, at one point said he was the worst president since Herbert Hoover, said the surge (of U.S. troops in Iraq) was the worst blunder since the Vietnam War, which is nonsense, and was anti-his own party and people," McCain said in an interview on Fox News on the day Republicans stalled Hagel's nomination.
Hagel didn't help his cause with his past opposition to unilateral penalties against Iran, his comment about the influence of the "Jewish lobby" in Washington, his support for reducing the nation's nuclear arsenal and remarks that created widespread doubts about his backing for Israel.
His halting and uneven performance at his confirmation hearing also hurt his nomination.
McCain, one of Hagel's friends during their years in the Senate, would have been a crucial vote to help sway other Republicans to back the nominee. Instead, he is one of more than a dozen opposing Hagel.
"I think he will have been weakened, but having said that, the job that he has is too important," McCain told reporters Friday during a visit to Mexico. "I know that I and my other colleagues, if he's confirmed, and he very likely will be, will do everything we can to work with him."
The nomination fight also is about the business of re-electing Republicans in 2014. Challenging the Democratic president over his nominations and policies is clearly a winner with the conservative base, a point not lost on GOP incumbents wary of challenges from the tea party.
South Carolina Republican Sen. Lindsey Graham, who's up for re-election next year, is getting high marks from Republicans for his relentless effort to get more information about the Sept. 11 attack in Benghazi, Libya, and his fierce opposition to Hagel.
"Most people down here think he's dead-on in his arguments and hope that he continues to press the issues," said Warren Tompkins, a longtime GOP strategist.
The Libya attack that killed Ambassador Chris Stevens and three other Americans has been a political flashpoint for Republicans who accused the Obama administration of an election-year cover-up of a terrorist assault.
An independent review conducted by respected former diplomats failed to mollify the GOP, who demanded testimony from Hillary Rodham Clinton, secretary of state when the attack occurred, and Defense Secretary Leon Panetta.
Graham has been at the forefront in seeking emails, communiques and videos while threatening to delay both Hagel's nomination and that of CIA Director-nominee John Brennan, who also has become entangled in the Libya dispute.
During a stop in Easley, S.C., this past week, Graham insisted that his effort has nothing to do with politics.
"It's not because he's a Democrat and I'm a Republican," he said, referring to Obama. "It's because it really was system failure and we need learn from it. We have not gotten the information, and we're going to get it if I have to die trying."
The White House has agreed to give the Senate Intelligence Committee additional documents related to the Benghazi attack, according to a congressional aide said. The material includes emails between national security officials showing the debate within the administration over how to describe the attack.
Graham also has been intense in opposing Hagel, portraying the former GOP senator as an out-of-the-mainstream radical. Some of the toughest questions of Hagel during his confirmation hearing last month came from Graham, who seized on Hagel's "Jewish lobby" remark and asked him to "name one dumb thing we've been goaded into doing due to pressure by the Israeli, Jewish lobby."
Hagel was often tentative in his response in the face of GOP grilling.
"He's leading, he's governing," Glenn McCall, the chairman of the York (S.C.) County Republican Party and a GOP committeeman, said of Graham. "More and more I talk to Republicans ? and even those that are conservative Democrats ? I think folks are looking for leadership."
Both Tompkins and McCall cited a Winthrop University poll released last week that showed Graham with strong support from registered Republicans in the state, with 72 percent holding a favorable opinion of the senator.
It's a turnaround from several years ago when Graham's work with Democrats on climate change and immigration as well as his votes for Obama's nominees for the Supreme Court angered South Carolina Republicans, with some calling him out of touch and Charleston and Lexington counties voting to censure him over his bipartisan work.
"It might be the right thing to do ... but when you partner with Hillary Clinton or you partner with John Kerry, you're going to be looked upon with a lot of suspicion in South Carolina," Tompkins said. "You have to be careful who you dance with."
Kerry, a former Democratic senator from Massachusetts, has just replaced Clinton as secretary of state.
Graham still may face a primary challenge, but he and other GOP incumbents are determined to head off any conservative uprising as Utah Sen. Orrin Hatch successfully did in his 2012 race. They want to avoid the fate of the only GOP primary loser last year ? Indiana's longtime Sen. Dick Lugar.
Texas Sen. John Cornyn, the No. 2 Republican and a candidate next year, took the lead on the Senate floor to block a vote on Hagel on Feb. 14 and was one of 15 Republicans last week to call for Obama to withdraw the nomination.
Cornyn got a primary challenger last week.
___
Follow Donna Cassata on Twitter: http://twitter.com/DonnaCassataAP
Source: http://www.startribune.com/politics/192698881.html
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Flipping the 'off' switch on cell growth: Protein uses multiple means to help cells cope when oxygen runs low
Feb. 22, 2013 ? A protein known for turning on genes to help cells survive low-oxygen conditions also slows down the copying of new DNA strands, thus shutting down the growth of new cells, Johns Hopkins researchers report. Their discovery has wide-ranging implications, they say, given the importance of this copying -- known as DNA replication -- and new cell growth to many of the body's functions and in such diseases as cancer.
"We've long known that this protein, HIF-1?, can switch hundreds of genes on or off in response to low oxygen conditions," says Gregg Semenza, M.D., Ph.D., a molecular biologist who led the research team and has long studied the role of low-oxygen conditions in cancer, lung disease and heart disorders. "We've now learned that HIF-1? is even more versatile than we thought, as it can work directly to stop new cells from forming." A report on the discovery appears in the Feb. 12 issue of Science Signaling.
With his team, Semenza, who is the C. Michael Armstrong Professor of Medicine at the Johns Hopkins University School of Medicine's Institute for Cell Engineering and Institute for Genomic Medicine, discovered HIF-1? in the 1990s and has studied it ever since, pinpointing a multitude of genes in different types of cells that have their activity ramped up or down by the activated protein. These changes in so-called "gene expression" help cells survive when oxygen-rich blood flow to an area slows or stops temporarily; they also allow tumors to build new blood vessels to feed themselves.
To learn how HIF-1?'s own activity is controlled, the team looked for proteins from human cells that would attach to HIF-1?. They found two, MCM3 and MCM7, that limited HIF-1?'s activity, and were also part of the DNA replication machinery. Those results were reported in 2011.
In the new research, Semenza and his colleagues further probed HIF-1?'s relationship to DNA replication by comparing cells in low-oxygen conditions to cells kept under normal conditions. They measured the amount of DNA replication complexes in the cells, as well as how active the complexes were. The cells kept in low-oxygen conditions, which had stopped dividing, had just as much of the DNA replication machinery as the normal dividing cells, the researchers found; the difference was that the machinery wasn't working. It turned out that in the nondividing cells, HIF-1? was binding to a protein that loads the DNA replication complex onto DNA strands, and preventing the complex from being activated.
"Our experiments answered the long-standing question of how, exactly, cells stop dividing in response to low oxygen," says Maimon Hubbi, Ph.D., a member of Semenza's team who is now working toward an M.D. degree. "It also shows us that the relationship between HIF-1? and the DNA replication complex is reciprocal -- that is, each can shut the other down."
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The above story is reprinted from materials provided by Johns Hopkins Medicine, via EurekAlert!, a service of AAAS.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- M. E. Hubbi, Kshitiz, D. M. Gilkes, S. Rey, C. C. Wong, W. Luo, D.-H. Kim, C. V. Dang, A. Levchenko, G. L. Semenza. A Nontranscriptional Role for HIF-1? as a Direct Inhibitor of DNA Replication. Science Signaling, 2013; 6 (262): ra10 DOI: 10.1126/scisignal.2003417
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/XQflXj1NWK4/130223111517.htm
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